Antonin Artaud was born in Marseille, France, to Euphrasie Nalpas and Antoine-Roi Artaud. Both his parents were natives of Smyrna (modern-day İzmir), and he was greatly affected by his Greek ancestry. His mother gave birth to nine children, but only Antonin and one sister survived infancy. When he was four years old, Artaud had a severe case of meningitis, which gave Artaud a nervous, irritable temperament throughout his adolescence. He also suffered from neuralgia, stammering and severe bouts of clinical depression, which was treated with the use of opium — resulting in a life-long addiction.

Artaud's parents arranged a long series of sanatorium stays for their temperamental son, which were both prolonged and expensive. This lasted five years, with a break of two months in June and July 1916, when Artaud was conscripted into the French Army. He was allegedly discharged due to his self-induced habit of sleepwalking. During Artaud's "rest cures" at the sanatorium, he read Arthur Rimbaud, Charles Baudelaire and Edgar Allan Poe. In May 1919, the director of the sanatorium prescribed laudanum for Artaud, precipitating a lifelong addiction to that and other opiates.